If you were to ask most people hunting for jobs if they would wear a novelty tie to a job interview, most would answer no. When asked why, they will offer several reasons, the most obvious of which is that they do not match the professional ensemble they are trying to achieve.
My article “Job Interview Tips – Wear Professional Attire Which Steers Clear of Novelty Neckties” talks about the obvious, that novelty ties are often meant to bring a chuckle, to be fun and funny and sometimes even weird and wacky, and a comical tone is not something a job applicant is seeking to reflect when they meet with a prospective employer.
Novelty ties may reflect your interests, but that can be better expressed on your resume.